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Robert L Hudkins Selected Research

Therapeutics

1/2012Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent.
1/2012CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities.

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Robert L Hudkins Research Topics

Disease

2Neoplasms (Cancer)
01/2012 - 12/2003
1Sleep Wake Disorders
01/2016
1Schizophrenia (Dementia Praecox)
01/2012
1Cognitive Dysfunction
07/2011
1Central Nervous System Diseases (CNS Diseases)
01/2010
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
02/2006
1Leukemia
02/2006
1Alzheimer Disease (Alzheimer's Disease)
01/2002
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2002

Drug/Important Bio-Agent (IBA)

26- (4- (3- (2- methylpyrrolidin- 1- yl)propoxy)phenyl)- 2H- pyridazin- 3- oneIBA
01/2012 - 07/2011
13- (1'- cyclobutylspiro(4H- 1,3- benzodioxine- 2,4'- piperidine)- 6- yl)- 5,5- dimethyl- 1,4- dihydropyridazin- 6- oneIBA
01/2016
1CytokinesIBA
01/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2012
1Antipsychotic Agents (Antipsychotics)IBA
01/2012
1Histamine (Histamine Dihydrochloride)FDA Link
07/2011
1Histamine H3 AntagonistsIBA
01/2010
1Proteins (Proteins, Gene)FDA Link
02/2006
1Anaplastic Lymphoma KinaseIBA
02/2006
1ProdrugsIBA
12/2003
1dimethylglycineIBA
12/2003
1compound 21IBA
12/2003
1EstersIBA
12/2003
1Transcription Factors (Transcription Factor)IBA
01/2002
1Phosphotransferases (Kinase)IBA
01/2002
13,9-bis((ethylthio)methyl)-K-252aIBA
01/2002

Therapy/Procedure

2Therapeutics
01/2012 - 01/2012